Altered pattern of motor cortical activation–inhibition during voluntary movements in Tourette syndrome
Identifieur interne : 001E57 ( Main/Exploration ); précédent : 001E56; suivant : 001E58Altered pattern of motor cortical activation–inhibition during voluntary movements in Tourette syndrome
Auteurs : Stephanie Franzkowiak [Allemagne] ; Bettina Pollok [Allemagne] ; Katja Biermann-Ruben [Allemagne] ; Martin Südmeyer [Allemagne] ; Jennifer Paszek [Allemagne] ; Melanie Jonas [Allemagne] ; Götz Thomalla [Allemagne] ; Tobias B Umer [Allemagne] ; Michael Orth [Allemagne] ; Alexander Münchau [Allemagne] ; Alfons Schnitzler [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-09-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Cortical Synchronization (physiology), Desynchronization, Evoked Potentials, Motor (physiology), Female, Fingers, Gilles de la Tourette syndrome, Humans, Magnetoencephalography, Male, Middle Aged, Motor Cortex (physiopathology), Motor cortex, Movement (physiology), Nervous system diseases, Neural Inhibition (physiology), Tourette Syndrome (physiopathology), event‐related desynchronization (ERD), magnetoencephalography (MEG), motor cortex, movement.
- MESH :
- physiology : Cortical Synchronization, Evoked Potentials, Motor, Movement, Neural Inhibition.
- physiopathology : Motor Cortex, Tourette Syndrome.
- Adult, Female, Fingers, Humans, Magnetoencephalography, Male, Middle Aged.
Abstract
In patients with Gilles de la Tourette syndrome (GTS) alterations of motor cortex (M1) excitability at rest have been evidenced. In contrast, there has so far been little research into changes of motor cortical reactivity during the time course of voluntary movements in GTS patients. The present study investigates neuromagnetic event‐related desynchronization (ERD) and event‐related synchronization (ERS) of bilateral M1 in 11 GTS patients and 11 healthy control subjects. ERD represents motor cortical activation, whereas ERS most likely indicates its inhibition. Subjects performed a self‐paced finger movement task while magnetoencephalography was used to record neuromagnetic activity. In GTS patients, ERD at beta frequency was significantly increased in the contralateral hemisphere before and during movements, whereas ERS following movement termination was increased in M1 ipsilateral. Ipsilateral ERS was inversely correlated with tic severity as determined by the Yale Global Tic Severity Rating Scale. The data of the present study support the hypothesis that during voluntary movements, motor cortical reactivity is pathologically altered in GTS patients. The observed pattern of increased activation (ERD) prior to and during movement execution followed by increased inhibition (ERS) after movement termination at beta frequency suggests abnormally increased motor cortical activation, possibly driving stronger inhibition. The stronger this inhibition is, the better symptoms appear to be controlled. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23186
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001548
- to stream Istex, to step Curation: 001548
- to stream Istex, to step Checkpoint: 000B36
- to stream PubMed, to step Corpus: 001700
- to stream PubMed, to step Curation: 001700
- to stream PubMed, to step Checkpoint: 001A47
- to stream Ncbi, to step Merge: 002D17
- to stream Ncbi, to step Curation: 002D17
- to stream Ncbi, to step Checkpoint: 002D17
- to stream Main, to step Merge: 002293
- to stream PascalFrancis, to step Corpus: 000920
- to stream PascalFrancis, to step Curation: 002399
- to stream PascalFrancis, to step Checkpoint: 000C09
- to stream Main, to step Merge: 002796
- to stream Main, to step Curation: 001E57
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Altered pattern of motor cortical activation–inhibition during voluntary movements in Tourette syndrome</title><author><name sortKey="Franzkowiak, Stephanie" sort="Franzkowiak, Stephanie" uniqKey="Franzkowiak S" first="Stephanie" last="Franzkowiak">Stephanie Franzkowiak</name></author><author><name sortKey="Pollok, Bettina" sort="Pollok, Bettina" uniqKey="Pollok B" first="Bettina" last="Pollok">Bettina Pollok</name></author><author><name sortKey="Biermann Uben, Katja" sort="Biermann Uben, Katja" uniqKey="Biermann Uben K" first="Katja" last="Biermann-Ruben">Katja Biermann-Ruben</name></author><author><name sortKey="Sudmeyer, Martin" sort="Sudmeyer, Martin" uniqKey="Sudmeyer M" first="Martin" last="Südmeyer">Martin Südmeyer</name></author><author><name sortKey="Paszek, Jennifer" sort="Paszek, Jennifer" uniqKey="Paszek J" first="Jennifer" last="Paszek">Jennifer Paszek</name></author><author><name sortKey="Jonas, Melanie" sort="Jonas, Melanie" uniqKey="Jonas M" first="Melanie" last="Jonas">Melanie Jonas</name></author><author><name sortKey="Thomalla, Gotz" sort="Thomalla, Gotz" uniqKey="Thomalla G" first="Götz" last="Thomalla">Götz Thomalla</name></author><author><name sortKey="B Umer, Tobias" sort="B Umer, Tobias" uniqKey="B Umer T" first="Tobias" last="B Umer">Tobias B Umer</name></author><author><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name></author><author><name sortKey="Munchau, Alexander" sort="Munchau, Alexander" uniqKey="Munchau A" first="Alexander" last="Münchau">Alexander Münchau</name></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E2745540F8CF8A938C861D7F0B4D14E13A85542F</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/mds.23186</idno><idno type="url">https://api.istex.fr/document/E2745540F8CF8A938C861D7F0B4D14E13A85542F/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001548</idno><idno type="wicri:Area/Istex/Curation">001548</idno><idno type="wicri:Area/Istex/Checkpoint">000B36</idno><idno type="wicri:doubleKey">0885-3185:2010:Franzkowiak S:altered:pattern:of</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:20669250</idno><idno type="wicri:Area/PubMed/Corpus">001700</idno><idno type="wicri:Area/PubMed/Curation">001700</idno><idno type="wicri:Area/PubMed/Checkpoint">001A47</idno><idno type="wicri:Area/Ncbi/Merge">002D17</idno><idno type="wicri:Area/Ncbi/Curation">002D17</idno><idno type="wicri:Area/Ncbi/Checkpoint">002D17</idno><idno type="wicri:Area/Main/Merge">002293</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:10-0446311</idno><idno type="wicri:Area/PascalFrancis/Corpus">000920</idno><idno type="wicri:Area/PascalFrancis/Curation">002399</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000C09</idno><idno type="wicri:doubleKey">0885-3185:2010:Franzkowiak S:altered:pattern:of</idno><idno type="wicri:Area/Main/Merge">002796</idno><idno type="wicri:Area/Main/Curation">001E57</idno><idno type="wicri:Area/Main/Exploration">001E57</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Altered pattern of motor cortical activation–inhibition during voluntary movements in Tourette syndrome</title><author><name sortKey="Franzkowiak, Stephanie" sort="Franzkowiak, Stephanie" uniqKey="Franzkowiak S" first="Stephanie" last="Franzkowiak">Stephanie Franzkowiak</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Neuroscience and Medical Psychology, Heinrich‐Heine University, Duesseldorf</wicri:regionArea><wicri:noRegion>Duesseldorf</wicri:noRegion><wicri:noRegion>Duesseldorf</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital Duesseldorf</wicri:regionArea><wicri:noRegion>University Hospital Duesseldorf</wicri:noRegion><wicri:noRegion>University Hospital Duesseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Pollok, Bettina" sort="Pollok, Bettina" uniqKey="Pollok B" first="Bettina" last="Pollok">Bettina Pollok</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Neuroscience and Medical Psychology, Heinrich‐Heine University, Duesseldorf</wicri:regionArea><wicri:noRegion>Duesseldorf</wicri:noRegion><wicri:noRegion>Duesseldorf</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital Duesseldorf</wicri:regionArea><wicri:noRegion>University Hospital Duesseldorf</wicri:noRegion><wicri:noRegion>University Hospital Duesseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Biermann Uben, Katja" sort="Biermann Uben, Katja" uniqKey="Biermann Uben K" first="Katja" last="Biermann-Ruben">Katja Biermann-Ruben</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Neuroscience and Medical Psychology, Heinrich‐Heine University, Duesseldorf</wicri:regionArea><wicri:noRegion>Duesseldorf</wicri:noRegion><wicri:noRegion>Duesseldorf</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital Duesseldorf</wicri:regionArea><wicri:noRegion>University Hospital Duesseldorf</wicri:noRegion><wicri:noRegion>University Hospital Duesseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Sudmeyer, Martin" sort="Sudmeyer, Martin" uniqKey="Sudmeyer M" first="Martin" last="Südmeyer">Martin Südmeyer</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Neuroscience and Medical Psychology, Heinrich‐Heine University, Duesseldorf</wicri:regionArea><wicri:noRegion>Duesseldorf</wicri:noRegion><wicri:noRegion>Duesseldorf</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital Duesseldorf</wicri:regionArea><wicri:noRegion>University Hospital Duesseldorf</wicri:noRegion><wicri:noRegion>University Hospital Duesseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Paszek, Jennifer" sort="Paszek, Jennifer" uniqKey="Paszek J" first="Jennifer" last="Paszek">Jennifer Paszek</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Neuroscience and Medical Psychology, Heinrich‐Heine University, Duesseldorf</wicri:regionArea><wicri:noRegion>Duesseldorf</wicri:noRegion><wicri:noRegion>Duesseldorf</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital Duesseldorf</wicri:regionArea><wicri:noRegion>University Hospital Duesseldorf</wicri:noRegion><wicri:noRegion>University Hospital Duesseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Jonas, Melanie" sort="Jonas, Melanie" uniqKey="Jonas M" first="Melanie" last="Jonas">Melanie Jonas</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Medical Center Hamburg‐Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Thomalla, Gotz" sort="Thomalla, Gotz" uniqKey="Thomalla G" first="Götz" last="Thomalla">Götz Thomalla</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Medical Center Hamburg‐Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="B Umer, Tobias" sort="B Umer, Tobias" uniqKey="B Umer T" first="Tobias" last="B Umer">Tobias B Umer</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Medical Center Hamburg‐Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Medical Center Hamburg‐Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm</wicri:regionArea><placeName><settlement type="city">Ulm</settlement><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Munchau, Alexander" sort="Munchau, Alexander" uniqKey="Munchau A" first="Alexander" last="Münchau">Alexander Münchau</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Medical Center Hamburg‐Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Neuroscience and Medical Psychology, Heinrich‐Heine University, Duesseldorf</wicri:regionArea><wicri:noRegion>Duesseldorf</wicri:noRegion><wicri:noRegion>Duesseldorf</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital Duesseldorf</wicri:regionArea><wicri:noRegion>University Hospital Duesseldorf</wicri:noRegion><wicri:noRegion>University Hospital Duesseldorf</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-09-15">2010-09-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1960">1960</biblScope><biblScope unit="page" to="1966">1966</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">E2745540F8CF8A938C861D7F0B4D14E13A85542F</idno><idno type="DOI">10.1002/mds.23186</idno><idno type="ArticleID">MDS23186</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Cortical Synchronization (physiology)</term><term>Desynchronization</term><term>Evoked Potentials, Motor (physiology)</term><term>Female</term><term>Fingers</term><term>Gilles de la Tourette syndrome</term><term>Humans</term><term>Magnetoencephalography</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (physiopathology)</term><term>Motor cortex</term><term>Movement (physiology)</term><term>Nervous system diseases</term><term>Neural Inhibition (physiology)</term><term>Tourette Syndrome (physiopathology)</term><term>event‐related desynchronization (ERD)</term><term>magnetoencephalography (MEG)</term><term>motor cortex</term><term>movement</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cortical Synchronization</term><term>Evoked Potentials, Motor</term><term>Movement</term><term>Neural Inhibition</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Motor Cortex</term><term>Tourette Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Fingers</term><term>Humans</term><term>Magnetoencephalography</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cortex moteur</term><term>Désynchronisation</term><term>Magnétoencéphalographie</term><term>Pathologie du système nerveux</term><term>Syndrome de Gilles de la Tourette</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In patients with Gilles de la Tourette syndrome (GTS) alterations of motor cortex (M1) excitability at rest have been evidenced. In contrast, there has so far been little research into changes of motor cortical reactivity during the time course of voluntary movements in GTS patients. The present study investigates neuromagnetic event‐related desynchronization (ERD) and event‐related synchronization (ERS) of bilateral M1 in 11 GTS patients and 11 healthy control subjects. ERD represents motor cortical activation, whereas ERS most likely indicates its inhibition. Subjects performed a self‐paced finger movement task while magnetoencephalography was used to record neuromagnetic activity. In GTS patients, ERD at beta frequency was significantly increased in the contralateral hemisphere before and during movements, whereas ERS following movement termination was increased in M1 ipsilateral. Ipsilateral ERS was inversely correlated with tic severity as determined by the Yale Global Tic Severity Rating Scale. The data of the present study support the hypothesis that during voluntary movements, motor cortical reactivity is pathologically altered in GTS patients. The observed pattern of increased activation (ERD) prior to and during movement execution followed by increased inhibition (ERS) after movement termination at beta frequency suggests abnormally increased motor cortical activation, possibly driving stronger inhibition. The stronger this inhibition is, the better symptoms appear to be controlled. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Tübingen</li><li>Hambourg</li></region><settlement><li>Hambourg</li><li>Ulm</li></settlement><orgName><li>Université d'Ulm</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Franzkowiak, Stephanie" sort="Franzkowiak, Stephanie" uniqKey="Franzkowiak S" first="Stephanie" last="Franzkowiak">Stephanie Franzkowiak</name></noRegion><name sortKey="B Umer, Tobias" sort="B Umer, Tobias" uniqKey="B Umer T" first="Tobias" last="B Umer">Tobias B Umer</name><name sortKey="Biermann Uben, Katja" sort="Biermann Uben, Katja" uniqKey="Biermann Uben K" first="Katja" last="Biermann-Ruben">Katja Biermann-Ruben</name><name sortKey="Biermann Uben, Katja" sort="Biermann Uben, Katja" uniqKey="Biermann Uben K" first="Katja" last="Biermann-Ruben">Katja Biermann-Ruben</name><name sortKey="Franzkowiak, Stephanie" sort="Franzkowiak, Stephanie" uniqKey="Franzkowiak S" first="Stephanie" last="Franzkowiak">Stephanie Franzkowiak</name><name sortKey="Jonas, Melanie" sort="Jonas, Melanie" uniqKey="Jonas M" first="Melanie" last="Jonas">Melanie Jonas</name><name sortKey="Munchau, Alexander" sort="Munchau, Alexander" uniqKey="Munchau A" first="Alexander" last="Münchau">Alexander Münchau</name><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name><name sortKey="Paszek, Jennifer" sort="Paszek, Jennifer" uniqKey="Paszek J" first="Jennifer" last="Paszek">Jennifer Paszek</name><name sortKey="Paszek, Jennifer" sort="Paszek, Jennifer" uniqKey="Paszek J" first="Jennifer" last="Paszek">Jennifer Paszek</name><name sortKey="Pollok, Bettina" sort="Pollok, Bettina" uniqKey="Pollok B" first="Bettina" last="Pollok">Bettina Pollok</name><name sortKey="Pollok, Bettina" sort="Pollok, Bettina" uniqKey="Pollok B" first="Bettina" last="Pollok">Bettina Pollok</name><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><name sortKey="Sudmeyer, Martin" sort="Sudmeyer, Martin" uniqKey="Sudmeyer M" first="Martin" last="Südmeyer">Martin Südmeyer</name><name sortKey="Sudmeyer, Martin" sort="Sudmeyer, Martin" uniqKey="Sudmeyer M" first="Martin" last="Südmeyer">Martin Südmeyer</name><name sortKey="Thomalla, Gotz" sort="Thomalla, Gotz" uniqKey="Thomalla G" first="Götz" last="Thomalla">Götz Thomalla</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E57 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001E57 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:E2745540F8CF8A938C861D7F0B4D14E13A85542F
|texte= Altered pattern of motor cortical activation–inhibition during voluntary movements in Tourette syndrome
}}
| This area was generated with Dilib version V0.6.23. |  |